Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1983-02-07
1986-05-06
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514867, A61K 31195
Patent
active
045872651
ABSTRACT:
Substantially nontoxic materials such as cysteamine constituting a source of sulfhydryl groups are useful in inhibiting diarrhea induced by Escherichia coli heat-stable enterotoxin. Such materials block ST-induced secretion prior to the formation of cyclic GMP without interference with normal basal activity or metabolism and may inactivate ST itself by breaking disulfide bridges.
REFERENCES:
CAs 66:12694e, 1966.
CAs 84:12,371u, 1976.
CAs 85:87,231c, 1976.
Broughler et al., J. Biol. Chem 254:12450-12454, 1979.
Mittal et al., PNAS, 74:4360-4364 1977.
Goldberg Jerome D.
Rollins Jr.
St. Louis University
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