Preparation of 2-chloro-5-chloromethylpyridine

Details Preparation of 2-chloro-5-chloromethylpyridine Preparation of 2-chloro-5-chloromethylpyridine

1989-12-04

1990-09-18

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21361

Patent

active

049580256

ABSTRACT:
A process for the preparation of 2-chloro-5-chloromethyl-pyridine of the formula ##STR1## which comprises reacting nicotinic acid of the formula ##STR2## with phosphorus pentachloride to produce 3-trichloromethylpyridine of the formula ##STR3## reacting the 3-trichloromethylpyridine in a 2nd step with an alkali metal alkoxide of the formula

REFERENCES:
patent: 4634771 (1987-01-01), Shim
Ziegler, Frederick, "Synthetic Studies . . . Yohimbine Alkaloids," J. Organic Chemistry, vol. 34, No. 11, pp. 3545-3548, Nov. 1969.

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