Oxazocinyl/thiazocinyl terminated alkylamino ethynyl alanine ami

Details Oxazocinyl/thiazocinyl terminated alkylamino ethynyl alanine ami Oxazocinyl/thiazocinyl terminated alkylamino ethynyl alanine ami

1994-01-25

1995-04-25

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540454, 540467, A61K 31395, A61K 3138, C07D26722, C07D28118

Patent

active

054099137

ABSTRACT:
Compounds characterized generally as oxazocinyl/thiazocinyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 ; wherein X is selected from oxygen atom and methylene; wherein B is a oxazocinyl/thiazocinyl group; wherein R.sub.1 is selected from hydrido, methyl, ethyl, isopropyl and n-propyl; wherein R.sub.2 is phenylmethyl; wherein each of R.sub.3 and R.sub.5 is hydrido; wherein R.sub.4 is selected from

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