Process for the production of lovastatin using Coniothyrium fuck

Details Process for the production of lovastatin using Coniothyrium fuck Process for the production of lovastatin using Coniothyrium fuck

1993-08-06

1995-04-25

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435135, 4352541, 514452, 549271, 549292, C12P 1706, A01N 4332, C07D31304

Patent

active

054098203

ABSTRACT:
A novel microorganism, Coniothyrium fuckelii ATCC 74227, and a process of using the microorganism for the production of lovastatin comprising fermenting Coniothyrium fuckelii ATCC 74227 or a lovastatin-producing mutant thereof in a nutrient medium containing assimilable sources of carbon, nitrogen, and inorganic salts under aerobic fermentation conditions.

REFERENCES:
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patent: 4231938 (1980-11-01), Monaghan et al.
patent: 4246258 (1981-01-01), Ayers et al.
patent: 4710313 (1987-12-01), Miyajima et al.
Akira Endo, J. Antibiotics, 32(8):852-854; "Monacollin K, a New Hypocholesterolemic Agent Produced by a Monascus Species"; Aug. 1979.
Akira Endo, Masao Kuroda and Yoshio Tsujita; J. Antibiotics, 29(12): 1346-1348; ML-236A, ML-236B, and ML-236C, "New Inhibitors of Cholesterogenesis Produced by Penicillium citrinum"; Dec. 1976.
A. Endo, Y. Tsujita, M. Kuroda and K. Tanzawa; Eur. J. Biochem., 77:31-36; "Inhibition of Cholesterol Synthesis in Vitro and in Vivo by ML-236A and ML-236B. Competitive Inhibitors of 3-Hydroxy-3Methylglutaryl-Coenzyme a Reductase"; Feb. 1977.
Allan G. Brown and Terry C. Smale; J.C.S. Perkin I, 1(11):1165-1170; "Crystal and Molecular Structure of Compactin, a New Antifungal Metabolite from Penicillium brevicompactum"; 1976.
A. W. Alberts et al.; Proc. Natl. Acad. Sci., 77(7):3957-3961, "Mevinolin: a Highly Potent Competitive Inhibitor of Hydroxymethylglutaryl-Coenzyme a Reductase and a Cholesterol-Lowering Agent"; Jul. 1980.
Akira Endo, Masao Kuroda and Kazuhiko Tanazawa; FEBS Letters, 72(2):323-326, "Competitive Inhibition of 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase by ML-236A and ML-236B Bungal Metabolites, Having Hypocholesterolemic Activity"; Dec. 1976.
ATCC Catalogue of Fungi/Yeasts, 17th Ed., 1987, p. 115.

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