Anti-receptor and growth blocking antibodies to the vitamin B.su

Details Anti-receptor and growth blocking antibodies to the vitamin B.su Anti-receptor and growth blocking antibodies to the vitamin B.su

1994-09-13

1997-11-18

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241421, 4241431, 4241521, 4241551, 4241561, A61K 3900

Patent

active

056885040

ABSTRACT:
There is disclosed anti-receptor and growth blocking agents to the vitamin B.sub.12 /transcobalamin II receptor and binding sites. The anti-receptor and growth blocking agents antagonize or modulate the vitamin B.sub.12 /transcobalamin II receptor or binding sites, causing cellular depletion of vitamin B.sub.12, thus preventing or inhibiting cell division or causing apoptosis. Anti-receptor and growth blocking agents of the present invention include proteins (such as antibodies and antibody derivatives), peptides and small organic molecules. In a preferred embodiment, the anti-receptor agent is an antibody to the vitamin B.sub.12 /transcobalamin II receptor.

REFERENCES:
Hall et al., "Cyclic Activity of the Receptors of Cobalamin Bound to Transcobalamin II," Journal of Cellular Physiology 133: 187-191, 1987.
Medline Database, Abstract #78000752 for the article Ostray and Gams, "Cellular fluxes of viamin B12," Blood 50(5): 877-88, 1977.
White et al., "Combinations of Anti-Transferrin Receptor Monoclonal Antibodies Inhibit Human Tumor Cell Growth in Vitro and in Vivo: Evidence for Synergistic Antiproliferative Effects," Cancer Research 50: 6295-6301, 1990.
Biosis Database, Abstract #78:184608, for the article Youngdahl-Turner et al., "Binding and uptake of trans cobalamin II by human fibroblasts," J. Clin. Invest. 61(1): 133-141, 1978.

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