Process for the preparation of an oxoetiocholenic acid

Details Process for the preparation of an oxoetiocholenic acid Process for the preparation of an oxoetiocholenic acid

1995-08-28

1997-07-22

Prior, Kimberly J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

540 7, 540 46, 552607, 552531, C07J 300, C07J 700, C07J 2100, C07J 4100

Patent

active

056505264

ABSTRACT:
The invention is drawn to a process for the preparation of oxoetiocholenic acid of the formula I ##STR1## by reacting a compound of the formula II ##STR2## with a halonitrile in the presence of a base followed by formation of a 3-ketone group. The intermediate formed is reacted with an acid of the formula HX in an anhydrous medium followed by dehydrohalogenation of the resulting compound in the presence of a base. The intermediate produced then undergoes alkaline hydrolysis followed by a conventional acid treatment to obtain the compound of formula I.

REFERENCES:
patent: 4179453 (1979-12-01), Johnston
patent: 4501701 (1985-02-01), Barton et al.
patent: 5504203 (1996-04-01), Buendia et al.
Copy of J.C.S. Chem. Comm., 1981, pp. 25-26, Kuren et al.

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