Process for the preparation of 9-deazaguanine derivatives

Details Process for the preparation of 9-deazaguanine derivatives Process for the preparation of 9-deazaguanine derivatives

1995-12-12

1997-07-22

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544117, 544238, 544244, 546330, 548251, 548253, 548254, 548255, 5482644, 5482648, 5482672, 549 77, 558386, 558401, 558404, 558405, 558406, 558410, 558428, 558429, 558430, 558432, C07D48704, C07F 96506, C07C25527

Patent

active

056505116

ABSTRACT:
Derivatives of 9-deazaguanine are prepared by reacting an aldehyde or ketone with a dialkylaminomalonate to form the corresponding enamine. The enamine is then reacted with a base to form a cyclic pyrrole. The cyclic pyrrole is reacted with an urea compound to provide a protected guanidino compound. The guanidino is converted to the desired 9-deazaguanine derivative by reacting with trifluoracetic acid or with an alkoxide or hydroxide followed by neutralization with an acid.

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