Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-05-31
1997-07-22
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 14, 514 15, 514 16, 514 21, 424 851, 435212, 530324, 530326, 530328, 530329, 530350, 530827, 530829, A61K 3800, A61K 4505, A61K 3804, C12N 948
Patent
active
056503920
ABSTRACT:
The present invention contemplates a composition and method for treating septic shock in a mammal or as a prophylactic treatment prior to a surgical procedure, comprising administering a therapeutically effective amount of a bacterial lipopolysaccharide binding peptide derived from CAP37 protein. In a preferred version, the composition and method of use may comprise a peptide comprising amino acids 20-44 of CAP37 or a subunit thereof.
REFERENCES:
patent: 5087569 (1992-02-01), Gabay et al.
patent: 5126257 (1992-06-01), Gabay et al.
Gabay, et al. Proc. Natl. Acad. Sci. U.S.A. 86:5610-5614.
Ziegler et al., "Treatment of Gram-Negative Bacteremia and Shock with Human Antiserum To A Mutant Escherichia Coli", The New England Journal of Medicine, vol. 307, No. 20, Nov. 11, 1982.
Baumgartner et al., "Prevention of Gram-Negative Shock and Death In Surgical Patients By Antibody to Endotoxin Core Glycolipid", The Lancet, Jul. 13, 1985, pp. 59-63.
Brackett et al., "Evaluation of Cardiac Output, Total Peripheral Vascular Resistance, and Plasma Concentrations of Vasopressin in the Conscious, Unrestrained Rat During Endotoxemia", Circulatory Shock, 17:273-284, 1985.
Fisher et al., "Initial Evaluation of Human Monoclonal Anti-Lipid A Antibody (HA-1A) in Patients with Sepsis Syndrome", Critical Care Medicine, vol. 18, No. 12, 1990, 1311-1315.
Greenman et al., "A Controlled Clinical Trial of E5 Murine Monoclonal IgM Antibody to Endotoxin in the Treatment of Gram-Negative Sepsis", JAMA, vol. 266, No. 8, Aug. 28, 1991, pp. 1097-1102 and 1125-1126.
J. Johnston, "Molecular Science Sets Its Sights on Septic Shock", The Journal of NIH Research, vol. 3, Oct. 1991, pp. 61-65.
Ziegler et al., "Treatment of Gram-Negative Bacteremia and Septic Shock With HA-1A Human Monoclonal Antibody Against Endotoxin", The New England Journal of Medicine, vol. 324, No. 7, Feb. 14, 1991, pp. 429-436.
"Anti-Endotoxin Monoclonal Antibodies", various editorials, The New England Journal of Medicine, vol. 327, No. 12, Sep. 17, 1992, pp. 889-890.
C. Welbourn and Y. Young, "Endotoxin, Septic Shock and Acute Lung Injury: Neutrophils, Macrophages and Inflammatory Mediators", Br. J. Surg., vol. 79, Oct. 1992, pp. 998-1003.
W. Ammons and A. Kung, "Recombinant Amino Terminal Fragment of Bactericidal/Permeability-Increasing Protein Prevents Hemodynamic Responses to Endotoxin", Circulatory Shock, 41:176-184, 1993.
Pereira et al., "Synthetic Bactericidal Peptide Based on CAP37: A 37kDa Human Neutrophil Granule-Associated Cationic Antimicrobial Protein Chemotactic for Monocytes", Proc. Natl. Acad. Sci. USA, vol. 90, pp. 4733-4737, May 1993.
S. Aldridge, "Meeting the Challenge of Sepsis", TIBTECH, vol. 11, Sep. 1993.
W. Hoffman, and C. Natanson, "Endotoxin in Septic Shock", Anesth Analg, 1993:77:613-24.
Stewart et al., "Comparison of Staphylococcus aureus and Escherichia coli Infusion in Conscious Rats", Journal of Surgical Research, 56, 60-66, 1994.
J. Gabay, "Ubiquitous Natural Antibiotics" Science, vol. 264, 15 Apr. 1994, pp. 373-374.
Brackett Daniel J.
Lerner Megan R.
Pereira Heloise Anne
Harle Jennifer
The Board of Regents of the University of Oklahoma
Tsang Cecilia J.
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