Apparatus having a rotatable stack of parallel trays with cultur

Details Apparatus having a rotatable stack of parallel trays with cultur Apparatus having a rotatable stack of parallel trays with cultur

1995-06-07

1997-07-22

Naff, David M.

Chemistry: molecular biology and microbiology

Apparatus

Bioreactor

43524023, 4352891, 4352982, 4352992, C12M 114, C12M 110, C12M 304, C12N 500

Patent

active

056503253

ABSTRACT:
An apparatus for providing an enhanced liquid/gas exchange surface such as during call culturing has an enclosed housing, a set of trays arranged in parallel inside the housing with a regular spacing between them, each of the trays being formed with a planar base, first rims on longitudinal sides and second rims on transverse sides of the trays projecting on both sides of the base so as to form retaining basins for retaining reaction liquid on both sides of the base as the trays are rotated through horizontal positions. In a preferred embodiment, the trays are stacked and have their first rims welded together to form the housing walls, while the second rims have a height lower than the first rims to create apertures between trays for fluid flow among the trays when they are rotated. The bases of the trays can have cutout portions on opposing transverse sides for the flow of reaction liquid from one side to the other. The trays can be fixed together to rotate inside a stationary housing, or can be mounted to inner walls of a rotatable housing. In a further embodiment, the trays have reduced-height second rims which are positioned at one lateral end with respect to the rotational axis to allow full drainage of fluid from that lateral end.

REFERENCES:
patent: 3839155 (1974-10-01), McAleer et al.
patent: 3925165 (1975-12-01), Muller
patent: 4310630 (1982-01-01), Girard et al.
patent: 4912058 (1990-03-01), Mussi et al.
patent: 5270205 (1993-12-01), Rogalsky

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