Inhibitor and anti-inhibitor monoclonal antibodies specific for

Details Inhibitor and anti-inhibitor monoclonal antibodies specific for Inhibitor and anti-inhibitor monoclonal antibodies specific for

1994-05-31

1997-07-22

Spiegel, Carol A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

435 74, 435 28, 4351722, 435962, 436512, 436518, 436523, 436531, 436537, 436548, 5303881, C07K 1600, C12P 2108

Patent

active

056503245

ABSTRACT:
Monoclonal antibodies have been prepared which are of the IgG isotype and are highly specific for horseradish peroxidase. One group of antibodies inhibits at least about 95% of the normal activity of horseradish peroxidase when bound to the enzyme. A second group of antibodies inhibits less than about 20% of the enzymatic activity when bound to the enzyme, but prevents the binding of the antibodies from the first group. The antibodies in either group can be conjugated to specific binding ligands such as drugs or hormones.

REFERENCES:
patent: 4621048 (1986-11-01), Ashihara et al.
patent: 4868109 (1989-09-01), Lansdrop
patent: 5085988 (1992-02-01), Olson
Marucci, Immunochemistry, 10, pp. 278-280, 1973.
Conroy et al, Immunochemistry, 13, pp. 599-603, 1976.
Conroy et al, Molecular Immunology, 19(5), pp. 659-663, 1982.
Conroy et al, Molecular Immunology, 20(6), pp. 647-653, 1983.
Boot et al, J. Immun. Methods, 103, pp. 69-77, 1987.
Tipton, Memphis State University thesis (Ph.D.), Dec., 1988.
Lansdorp et al, Methods in Enzymology, vol. 21. pp. 855-867, 1986.
Kim et al, "Evaluation of dissociation contants of antigen-antibody complexes by ELISA," Journal of Immunological Methods 131 (1990) pp. 213-222.
Tipton et al., "Epitope Mapping of Horseradish Peroxidase with Use of Monoclonal Antibodies," Hybridoma 9(1990): pp. 319-330.
Biological Abstract 88(8):85479 issued 1989.
Chemical Abstract 103(1):4883.
Biological Abstract 98(8):101871.

Affiliated with

Also associated with

Rating

Inhibitor and anti-inhibitor monoclonal antibodies specific for does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitor and anti-inhibitor monoclonal antibodies specific for , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitor and anti-inhibitor monoclonal antibodies specific for will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1559516