Analgesic, relaxant, and anti-inflammatory cyclopentanol derivat

Details Analgesic, relaxant, and anti-inflammatory cyclopentanol derivat Analgesic, relaxant, and anti-inflammatory cyclopentanol derivat

1976-08-24

1978-08-22

Douglas, Winston A.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Lipid or oil

2603457R, 2603457P, 2603458R, 2603458P, 260514D, 260514K, 260586R, 424305, 424317, 424331, 542429, 560122, A61K 31045, A61K 3135, C07D30922, C07D30906

Patent

active

041090098

ABSTRACT:
Novel cyclopentanol compounds of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## R' is selected from the group consisting of hydrogen, alkyl of 1 to 12 carbon atoms and a non-toxic, pharmaceutically acceptable cation, R" is alkyl of 1 to 6 carbon atoms, R.sub.1 is selected from the group consisting of hydrogen and straight or branched chain, saturated and unsaturated alkyl of 1 to 4 carbon atoms and R.sub.2 is selected from the group consisting of hydrogen and tetrahydropyranyl, the wavy lines connecting R and --OH to the cyclopentane ring and --OR.sub.2 and R.sub.1 to the chain indicates that the substituents may be in either of the possible positions on the carbon atom to which they are attached and the dotted line indicates the optional presence of a double bond which possess analgesic, anti-inflammatory and smooth muscle relaxant activity and their preparation.

REFERENCES:
patent: 3806535 (1974-04-01), Sakai et al.
patent: 3839430 (1974-10-01), Leeming et al.
patent: 3867377 (1975-02-01), Kluge et al.
patent: 3868402 (1975-02-01), Martel et al.
patent: 3931297 (1976-01-01), Crabbe
patent: 3984459 (1976-10-01), Babej et al.
Caton et al. "Prostaglandins II . . . "in Tetrahedron Ltrs. 32, pp. 3341-3344, 1972.
Hamon, A. "Synthesis of Prostanoic Acid" in Tetrahedron Ltrs. No. 50, pp. 4482, 4481, 1975, Sep. 1.

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