Process for resolving chiral acids with 1-aminoindan-2-ols

Details Process for resolving chiral acids with 1-aminoindan-2-ols Process for resolving chiral acids with 1-aminoindan-2-ols

1995-05-18

1997-10-14

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562401, 562460, 562466, 562492, 562493, C07D30702

Patent

active

056774699

ABSTRACT:
A process for the full or partial resolution of a mixture of enantiomers of a genus of chiral carboxylic acids is disclosed. The process uses a pure enantiomer of 1-aminoindan-2-ol as the resolving agent and achieves separation of the diastereomeric salts by fractional crystallization followed by liberation of the chiral acid from the salt by treatment with mineral acid. Diastereomeric salts and solyates of those salts are disclosed. The production of ketoprofen, flurbiprofen and other chiral medicaments and precursors thereto is disclosed.

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Didier et al. "Chemo-Enzymatic Synthesis of 1,2- and 1,3- Amino-Alcohols and Their Use . . . " Tetrahedron 47, 4941-4958 (1991).

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