Method of preparation of 2',3'-dideoxynucleosides

Details Method of preparation of 2',3'-dideoxynucleosides Method of preparation of 2',3'-dideoxynucleosides

1988-08-02

1991-01-22

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 24, 536124, C07H 19073, C07H 19173

Patent

active

049872249

ABSTRACT:
A general method of synthesis of 2',3'-dideoxynucleosides which is efficient, inexpensive and based on a readily available starting material, D-mannitol.

REFERENCES:
patent: 3282921 (1966-11-01), Verheyden et al.
patent: 3687931 (1972-08-01), Verheyden et al.
patent: 3755295 (1973-08-01), Verheyden et al.
patent: 3755397 (1973-11-01), Etzold et al.
patent: 3817982 (1974-06-01), Verheyden et al.
patent: 4071680 (1978-01-01), Cook
patent: 4230689 (1980-10-01), Bobek et al.
patent: 4526988 (1985-07-01), Hertel et al.
patent: 4604382 (1986-08-01), Lin et al.
Anzai, et al., Agr. Biol. Chem. 37 (2), 345 (1973).
Baer, E., Biochemical Preparations, vol. 2, Editors E. G. Ball, John Wiley, New York, 1952, pp. 31-39.
Baker, Joseph and Schaub, J. Am. Chem. Soc. 5905 (1955).
Baker, Schaub and Williams, J. Am. Chem. Soc. 77, 7 (1955).
Broker, Modern Concepts and Therapeutic Challenges, AIDS, p. 303, Marcel Dekker, Inc., New York 1987.
Classon, et al., Acta Chemica Scandinavica B36, 251 (1982).
Colla, et al., Eur. J. Med. Chem.-Chim. Ther. 20(4), 295 (1985).
Chem. Abstract 101:192378c (1984).
Chem. Abstract 98:4753u (1983).
Chem. Abstract 96:69346s (1982).
Chem. Abstract 105:227205f (1986).
Dyatkina, N. B. Soviet J. Biorg. Chem. 12, 563 (1986).
Dyatkina and Azhayev, Synthesis 961 (Nov. 1984).
Fleet, Son and Drome, Tetrahedron 44 (2), 625 (1988).
Furman, et al., Proc. Nat'l Acad. Sci., U.S.A. 83, 8333 (1986).
Hafele and Jager, Liebigs Ann. Chem. 85 (1987).
Herdewijn, et al., J. Med. Chem. 30, 1270 (1987).
Horowitz, et al., J. Org. Chem. 29, 2076 (1984).
Horowitz, et al., J. Am. Chem. Soc. 86, 1896 (1964).
Horowitz, et al., J. Org. Chem. 31, 205 (1966).
Horowitz, et al., J. Org. Chem. 32, 817 (1967).
Horowitz, et al., Tetrahedron Letters 1343 (1966).
Jain, et al., J. Org. Chem. 39, 30 (1974).
Lin, et al., J. Med. Chem. 30, 440 (1987).
Lin, et al., J. Med. Chem. 21(1) 109 (1978).
Lin, et al., J. Med. Chem. 26, 1691 (1987).
Lin, T. S., et al., J. Med. Chem. 26, 544 (1983).
Krenitsky, et al., J. Med. Chem. 26(6) 891 (1983).
McCarthy, et al., J. Am. Chem. Soc. 88, 1549 (1966).
Mitsuya, et al., Nature, 325, 773 (1987).
Mitsuya, et al., Proc. Natl. Acad. Sci. U.S.A. 82, 7096 (1985).
Prisbe and Martin, Synthetic Communications 15 (5), 401 (1985).
Robins, et al., Tetrahedron Letters 25, 367 (1984).
Russell, et al., J. Am. Chem. Soc. 95 4025 (1973).
Tong, et al., J. Org. Chem. 30, 2854 (1965).
Webb, et al., Nucleosides and Nucleotides 7 (2), 147 (1988).
Yarcoan, et al., New England Journal of Medicine, 316, 557 (1987).
Lin, et al., Biochemical Pharmocol. 36 (17) 2713 (1987).
Chemical Abstracts 76:99976b (1972) Novak et al., Collect. Czech. Chem. Commun. 1971, 36(11) 3670-7.
Danilova et al. (1986) Tetrahedron Letters 27, 2489-2490.
Beer et al., (1982) Helv. Chim. Acta 65, 2570-2582.

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