Paramagnetic metal icon chelates and use thereof as contrast age

Details Paramagnetic metal icon chelates and use thereof as contrast age Paramagnetic metal icon chelates and use thereof as contrast age

1995-05-17

1997-07-22

Kamm, William E.

Surgery

Truss

Pad

424 93, A61B 5055

Patent

active

056495374

ABSTRACT:
Novel paramagnetic metal ion chelates and their use as contrast agents in the diagnostic technique known as "magnetic resonance imaging" (M.R.I.) of the gastrointestinal tract and particularly of the liver, are described. The novel compounds result from the conjugation of a bile acid with a chelating agent and are capable of chelating the ions of bivalent and trivalent metals. The compounds have formula A-L-B in which A is the residue of a bile acid and derivatives of a bile acid, B is the residue of a chelating agent of a bivalent or trivalent metal ion having an atomic number of 20 to 31, 39, 42, 43, 44, 49, 57 to 83, L is a ligand between A and B.

REFERENCES:
patent: 5021236 (1991-06-01), Gries et al.
patent: 5169944 (1992-12-01), Nelson et al.
patent: 5358704 (1994-10-01), Desreaux et al.
patent: 5474756 (1995-12-01), Tweedle et al.
patent: 5527522 (1996-06-01), Lauffer et al.

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