Process for the preparation of 2-chloro-5-aminomethyl-pyridine

Details Process for the preparation of 2-chloro-5-aminomethyl-pyridine Process for the preparation of 2-chloro-5-aminomethyl-pyridine

1993-07-01

1995-09-26

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546286, C07D21361

Patent

active

054535069

ABSTRACT:
Process for the preparation of 2-chloro-5-aminomethylpyridine of the formula (I) ##STR1## by a reaction of 2-chloro-5-cyano-pyridine of the formula (II) ##STR2## with hydrogen in the presence of ammonia and in the presence of an anhydrous metal catalyst, characterized in that the reaction is carried out in an apolar aprotic diluent at temperatures between 20.degree. C. and 150.degree. C.

REFERENCES:
patent: 4499097 (1985-02-01), Tomcufcik et al.
patent: 5360650 (1994-04-01), Nabata
Chemical Abstract, vol. 81, No. 13, Abstract 77.810u, p. 452 (Sep. 30, 1974).
European Patent Office, Database WPI, Week 9236, Derwent Publications, AN-92-299951, JP 4247069, Koei Chem. Ind. Co. Feb. 4, 1991. (1 page).
European Patent Office, Database WPI, Week 8651, Derwent Publications, AN 86-336001, JP 61251663, Koei Chem. Ind. Nov. 8, 1986. (1 page).
European Patent Office, Database WPI, Week 7913, Derwent Publications, AN 79-24478B, JP 54022354, Sagami Chem. Res. Centre, Feb. 20, 1979. (1 page).
Chemical Abstracts, page 713, 27-Heterocycles, vol. 111, 1989; No. 173988s, "Preparation of the Antihypertensive Intermediate . . . ", F. Maurer, Bayer AG, Aug. 13, 1987.

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