Process for preparing alpha-anomer enriched 1-halo-2-deoxy-2,2-d

Details Process for preparing alpha-anomer enriched 1-halo-2-deoxy-2,2-d Process for preparing alpha-anomer enriched 1-halo-2-deoxy-2,2-d

1993-07-29

1995-09-26

Wityshyn, Michael G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536124, 549475, 549476, C07H 502, C07H 100

Patent

active

054534992

ABSTRACT:
A stereoselective process for preparing an alpha-anomer enriched 1-.alpha.-halo-2-deoxy-2,2-difluoro-D-ribofuranosyl derivatives involving contacting a 3,5-hydroxy protected-2-deoxy-2,2-difluoro-D-ribofuranosyl-1-.beta.-sulfonate with a halide source in an inert solvent.

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patent: 5252756 (1993-10-01), Chou et al.
patent: 5256797 (1993-10-01), Chou et al.
patent: 5256798 (1993-10-01), Chou et al.
Cancer Research, vol. 49, issued 01 Aug. 1989, Tietze et al, "Proton14 mediated Liberation of Aldophosphamide from a Nontoxic Prodrug: A Strategy for Tumor-Selective Activation of Cytocidal Drugs" pp. 4179-4184.

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