Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1975-08-11
1977-12-06
Gerstl, Robert
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
260514D, 260520B, C07C17700
Patent
active
040618650
ABSTRACT:
Prostaglandin compounds of the formula: ##STR1## wherein A represents a grouping of formula II, III or IV indicated below and (i)R.sub.1 represents an unsubstituted n-butyl, n-pentyl, n-hexyl or n-heptyl radical, or such a radical carrying one, two or three alkyl substituents of 1 to 4 carbon atoms, or R.sub.1 represents a methyl, ethyl, propyl or butyl radical carrying a phenyl, cyclohexyl or cyclopentyl substituent, R.sub.2 represents a hydrogen atom or an alkyl radical of 1 to 4 carbon atoms, and R.sub.3 represents a hydrogen atom, or (ii) R.sub.1 represents n-butyl, or n-butyl or n-pentyl carrying one, two or three alkyl substituents of 1 to 4 carbon atoms, or R.sub.1 represents a methyl, ethyl, propyl or butyl radical carrying a phenyl, cyclohexyl or cyclopentyl substituent, R.sub.2 represents a hydrogen atom or an alkyl radical of 1 to 4 carbon atoms, and R.sub.3 represents an alkyl radical of 1 to 4 carbon atoms are disclosed. These compounds exhibit characteristic prostaglandin-like activity.
REFERENCES:
patent: 3816393 (1974-06-01), Hayashi et al.
Hamberg et al., Ann., N. Y., Acad. Sci., 180, 175 (1971).
Hayashi Masaki
Ito Hiroyuki
Ohyama Isao
Tanouchi Tadao
Chow Frank S.
Gerstl Robert
Graddis Albert H.
Ono Pharmaceutical Company
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