Anti-hypertensive chromans and chromenes

Details Anti-hypertensive chromans and chromenes Anti-hypertensive chromans and chromenes

1984-05-16

1986-02-18

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514242, 514241, 514444, 549404, 549399, 514443, 549345, 549 60, 514422, 549 57, 549 55, 514414, 549 54, 549 52, 514409, 549 51, 548525, 514397, 548454, 548407, 514380, 548336, 548236, 514378, 548216, 548214, 514377, 548213, 548189, 514376, 548188, 548147, 514374, 548136, 548134, 514372, 548130, 548129, 514371, 548128, 548127, 514370, 546269, 544405, 514369, 544333, 544298, 514365, 544240, 544239, 514363, 544238, 544230, 514362, 514361, 514337, 514314, 514313, 514312, 514307, 514278, 514275, 514274, 514272,

Patent

active

045714061

ABSTRACT:
Compounds of formula (I): ##STR1## wherein: either one of R.sub.1 and R.sub.2 is hydrogen and the other is selected from the class of C.sub.1-6 alkylcarbonyl, C.sub.1-6 alkoxycarbonyl, C.sub.1-6 alkylcarbonyloxy, C.sub.1-6 alkylhydroxymethyl, nitro, cyano, chloro, trifluoromethyl, C.sub.1-6 alkylsulphinyl, C.sub.1-6 alkylsulphonyl, C.sub.1-6 alkoxysulphinyl, C.sub.1-6 alkoxysulphonyl, C.sub.1-6 alkylcarbonylamino, C.sub.1-6 alkoxycarbonylamino, C.sub.1-6 alkyl-thiocarbonyl, C.sub.1-6 alkoxy-thiocarbonyl, C.sub.1-6 alkyl-thiocarbonyloxy, 1-mercapto C.sub.2-7 alkyl, formyl or aminosulphinyl, aminosulphonyl or aminocarbonyl, the amino moiety being optionally substituted by one or two C.sub.1-6 alkyl groups, or C.sub.1-6 alkylsulphinylamino, C.sub.1-6 alkylsulphonylamino C.sub.1-6 alkoxysulphinylamino or C.sub.1-6 alkoxysulphonylamino, or ethylenyl terminally substituted by C.sub.1-6 alkylcarbonyl, nitro or cyano, or --C(C.sub.1-6 alkyl)NOH or --C(C.sub.1-6 alkyl)NNH.sub.2, or one of R.sub.1 and R.sub.2 is nitro, cyano or C.sub.1-3 alkylcarbonyl and the other is methoxy or amino optionally substituted by one or two C.sub.1-6 alkyl or by C.sub.2-7 alkanoyl;

REFERENCES:
patent: 4363811 (1982-12-01), Evans et al.
patent: 4366163 (1982-12-01), Evans et al.
patent: 4446113 (1984-05-01), Evans et al.
Lap et al., Aust. J. Chem., 1979, 32 pp. 619-636.

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