Method for preparing (+)R-2-methyl-hexane-1,2-diol

Details Method for preparing (+)R-2-methyl-hexane-1,2-diol Method for preparing (+)R-2-methyl-hexane-1,2-diol

1986-01-08

1986-12-30

Evans, J. E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

549430, 568844, C07C 2900, C07C 3120

Patent

active

046330259

ABSTRACT:
A method for preparing important stereospecific intermediates in the synthesis of prostaglandin analogs is disclosed. Said intermediates are (+)R-2-methyl-hexane-1,2-diol and (-)S-2-methyl-hexane-1,2-diol and are prepared via an asymmetric halolactonization reaction utilizing L-proline and D-proline, respectively as the chiral agent.

REFERENCES:
patent: 2078534 (1937-04-01), Groll et al.
patent: 4313008 (1982-01-01), Jones
Byers et al, "J. Chem. Soc.", (1948), pp. 1328-1331.

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