Monoclonal antibodies which block infectivity of malarial parasi

Details Monoclonal antibodies which block infectivity of malarial parasi Monoclonal antibodies which block infectivity of malarial parasi

1983-10-31

1986-12-30

Hazel, Blondel

Chemistry: analytical and immunological testing

Involving immune complex formed in liquid phase

Separation of immune complex from unbound antigen or antibody

435 68, 435240, 436548, 424 85, 935104, 935107, 935110, G01N 33536, C12N 500, A61K 39395, C12P 2100

Patent

active

046329099

ABSTRACT:
Monoclonal antibodies have been developed that bind with one or more proteins located on the surface of gametes or zygotes of malaria parasites. These antibodies are specific for antigens on mosquito midgut stages of malaria parasite and sterilize the parasites in mosquitoes otherwise capable of transmitting the disease. The monoclonal antibodies are specific for the 255, 59 and 53 kilodalton surface proteins on Plasmodium falciparum and for the 25 kilodalton surface protein on zygotes and ookinetes of Plasmodium gallinaceum.

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