Process for production of prostaglandin intermediates

Details Process for production of prostaglandin intermediates Process for production of prostaglandin intermediates

1992-09-01

1993-12-28

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549396, C07D31100

Patent

active

052741303

ABSTRACT:
The isomer ratio of a cis-isomer against the corresponding trans-isomer with respect to the 5-6 double bond is improved in the production of prostaglandins, when a lactol is reacted with an ylide to cause simultaneously formation of the 5-double bond and an .alpha.-chain, whereby the ylide generated from a phosphonium salt with a potossium base, and a solvent which is liquid at the reaction temperature and has a dipole moment of 0.3 to 3.0D are used.

REFERENCES:
patent: 3933898 (1976-01-01), Nelson
patent: 4259481 (1981-03-01), Johnson
Journal of Medicinal Chemistry, vol. 21, No. 5, pp. 443-447, 1978.
Chem. Pharm. Bull. 28(5), 1422-1431 (1980).

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