Method for reducing sickle erythrocyte dehydration and delaying

Details Method for reducing sickle erythrocyte dehydration and delaying Method for reducing sickle erythrocyte dehydration and delaying

1992-11-02

1993-12-28

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514396, 514399, 514815, A61K 31415

Patent

active

052739929

ABSTRACT:
The present invention provides a chemical class of active compounds to be used as efficacious drugs in the treatment of sickle cell disease. The active compounds include imidazole derivatives, nitroimidazole derivatives, and triazole derivatives. These compounds are to be administered by any preferred route of administration including oral, intramuscular, intravenous, and any other parenteral route. If desired, these drugs may also be administered transmucosally, or subcutaneously, or using a dermal patch on the skin. In addition, the methodology is effective for both long term and short term therapy; may be employed prophylactically and/or therapeutically; and may be used in emergency, acute crisis clinical situations.

REFERENCES:
patent: 4343808 (1982-08-01), Broersma, Jr. et al.
patent: 4696937 (1987-09-01), Sebille et al.
Swamy et al., Chem. Abstracts CA85(9):56689d, 1976.
Chang et al., Medline 83244512(NLM), May 1983.

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