Non-histological cell type determination

Details Non-histological cell type determination Non-histological cell type determination

1988-06-30

1993-12-28

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, 435 72, 435 723, 435820, 435961, 436501, 436503, 436 63, 436 64, 436813, C12Q 168, G01N 3353, G01N 33574

Patent

active

052738779

ABSTRACT:
Disclosed are non-histological methods for determining the presence in a sample of a preselected cell type such as a malignant or genetically defective cell, or cell nucleus debris from such cells. The methods involve determination of an intranuclear matrix protein, the mRNA encoding that protein, or matrix protein associated DNA or RNA which acts as a marker for the preselected cell type, the presence of which indicates the presence of the cell type in the test sample. The intranuclear matrix marker protein or nucleotide are detected by hybridization, immunoassay, or other known means.

REFERENCES:
patent: 4358535 (1982-11-01), Falkow
patent: 4366241 (1982-12-01), Tom et al.
patent: 4569916 (1986-02-01), Penman
Anderson et al., 30 (12) Clin. Chem. 1898-1905 (1984).
Barrack et al., 255 J. Biol. Chem. 7265-75 (1980).
Barrack et al, Recent Progress in Hormone Research, Roy O. Greep, (ed.) vol. 38, 133-137, and 180-189 (Academic Press, New York, 1982).
Berezney et al., 189(4199) Science 291-93 (1975).
Berezney et al., 14 Adv. Enzyme Regul. 63-100 (1976).
Berezney et al., 73 J. Cell Biol. 616-37 (1977).
Berezney et al., 85 J. Cell Biol. 641-50 (1980).
Bhorjee et al., 97 J. Cell Biol. 389-96 (1983).
Bludau et al., 165 Exper. Cell Res. 269-82 (1986).
Bodnar et al., 3 (9) Mol. Cell Biol. 1567-79 (1983).
Brasck et al., 54(2) Biol. Cell 109-21 (1985).
Briggs et al., 21 J. Cellular Biochem. 249-62 (1983).
Burdon et al., 825(1) Biochim. Biophys. Acta. 70-79 (1985).
Buttyan et al., 258(23) J. Biol. Chem. 14366-70 (1983).
Caizergues-Ferrer et al., 118(2) Biochem. Biophys. Res. Com. 440-50 (1984).
Capco et al., 29(3) Cell 847-58 (1982).
Chaly et al., 99 J. Cell Biol. 661-71 (1984).
Chaly et al., 63 Can. J. Biochem. Cell Biol. 644-53 (1985).
Chaly et al., 10(6) Cell Biol. Inter. Reports 421-28 (1986).
Chiu et al., 107 Rad. Res. 24-38 (1986).
Comings et al., 103 Exp. Cell Res. 341-60 (1976).
Detke et al., 257(7) J. Biol. Chem. 3905-11 (1982).
Eastment et al., 57(4) Blood 747-57 (1981).
Eisenman et al., 5(1) Mol. Cell. Biol. 114-26 (1985).
Fey et al., 98(6) J. Cell Biol. 1973-84 (1984).
Fey et al., 99 (1, Pt 2) J. Cell Biol. 203s-08s (1984).
Fey et al., 81(14) Proc. Natl. Acad. Sci. USA 4409-13 (1984).
Fey et al., 102 J. Cell Biol. 1654-65 (1986).
Fisher et al., 92(3) J. Cell Biol. 674-86 (1982).
Flickinger, 10(6) Cell Biol. Internat. Reports 415-20 (1986).
Franklin et al., 24 J. Cell Biochem. 1-14 (1984).
Hapbets et al., 54(1) Clin. Exp. Immunol. 265-76 (1983); 99(23) Chem. Abstracts No. 192945A (1983).
Hentzen et al., 81(2) Proc. Natl. Acad. Sci. USA 304-07 (1984).
Hodge et al., 72(1) J. Cell Biol. 194-208 (1977).
Intres et al., 21(11) In Vitro Cell Dev. Biol. 641-48 (1985).
Kaufman et al., 132 Exp. Cell Res. 105-23 (1981).
Kaufman et al., 155 Exp. Cell Res. 477-95 (1984).
Kirsch et al., 137(2) Biochem. Biophys. Res. Comm. 640-48 (1986).
Kuzmin et al., 25(20) Eur. J. Cell. Biol. 225-32 (1981).
Lehner et al., 162(1) Exp. Cell Res. 205-19 (1986).
Long et al., 18 Cell 1079-90 (1979).
Long et al, 48 Biol. Cell 99-108 (1983).
MacDonald et al., 138(1) Biochem. Biophys. Res. Comm. 254-60 (1986).
Martelli et al., 103(5, Pt. 2) J. Cell Biol. 181 (1986).
Milavetz et al., 134(2) Virology 406-20 (1984).
Milavetz et al., 127 J. Cell. Physiol. 358-96 (1986).
Moy et al., 46 Cancer Res. 4672-76 (1986).
Mullenders et al., 698 Biochim. Biophys. Acta. 70-77 (1982).
O'Farrell et al., 10 J. Biol. Chem. 4007-21 (1975).
O'Farrell et al., 82 J. Cell Sci. 173-

Affiliated with

Also associated with

Rating

Non-histological cell type determination does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-histological cell type determination, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-histological cell type determination will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1542093