Process and intermediates for the synthesis of vitamin D.sub.3 m

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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2603974, 26023955R, C07J 900

Patent

active

043104673

ABSTRACT:
The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D.sub.3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via intermediates having the natural steroid configuration at the 20-position. These novel intermediates are prepared from 17-keto steroids by reaction with ethyltriphenylphosphonium halides followed by reaction with formaldehyde to form comounds having the natural steroid configuration at the 20-position and which are suitable substrates for the preparation of the aforementioned Vitamin D.sub.3 metabolites.

REFERENCES:
patent: 3994934 (1976-11-01), Salmond
patent: 4193921 (1980-03-01), Furst et al.

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