Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1980-10-22
1982-01-12
Roberts, Elbert L.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2603974, 26023955R, C07J 900
Patent
active
043104673
ABSTRACT:
The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D.sub.3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via intermediates having the natural steroid configuration at the 20-position. These novel intermediates are prepared from 17-keto steroids by reaction with ethyltriphenylphosphonium halides followed by reaction with formaldehyde to form comounds having the natural steroid configuration at the 20-position and which are suitable substrates for the preparation of the aforementioned Vitamin D.sub.3 metabolites.
REFERENCES:
patent: 3994934 (1976-11-01), Salmond
patent: 4193921 (1980-03-01), Furst et al.
Batcho Andrew D.
Berger, Jr. Donald E.
Uskokovic Milan R.
Callwood James H.
Hoffmann-La Roche Inc.
Leon Bernard S.
Roberts Elbert L.
Saxe Jon S.
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