Isolated nonapeptides derived from MAGE genes and uses thereof

Details Isolated nonapeptides derived from MAGE genes and uses thereof Isolated nonapeptides derived from MAGE genes and uses thereof

1992-08-31

1995-04-11

Walsh, Stephen G.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530300, 4241851, C07K 704, A61K 3702

Patent

active

054059402

ABSTRACT:
The invention involves the reception of particular nonapeptides by HLA molecules. The nonapeptides are derived from expression products of the MAGE gene family. The resulting complexes are identified by cytolytic T cells. Such recognition may be used in diagnostics, or therapeutically.

REFERENCES:
patent: 5030621 (1991-07-01), Bystryn
patent: 5141742 (1992-08-01), Brown
Barinaga, Science 257: 880 (Aug. 14, 1992).
Van Der Bruggen, Science 254: 1643-1647 (Dec. 13, 1992).
Szikora, EMBO J 9(4): 1041-1050 (1990).
Sibbile, J. Exp. Med. 172: 35-45 (Jul. 1990).
Lurquin, Cell 58: 293-303 (Jul. 28, 1989).
Van Den Eynde, Int. J. Canc. 44: 634-640 (1989).
Boon, in Melchers et al., Progress in Immun., vol. VII (1989), pp. 1063-1070.
DePlaen, Proc. Natl. Acad. Sci. 85: 2274-2278 (Apr. 1988).
Wolfel, Immunogenetics 26: 178-187 (1987).
Boon, J. Exp. Med. 152: 1184-1193 (1988).
Traversari et al "A Nonapeptide Encoded by Human Gene MAGE -1 . . . " J. Exp. Med. 176: 1453-1457 (Nov. 1992).
Rotzschke et al "Isolation and analysis of naturally processed viral peptides . . . " Nature 348: 252-254 (Nov. 1990).
Allen et al "Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope" Nature 327: 713-715 (Jun. 1987).

Affiliated with

Also associated with

Rating

Isolated nonapeptides derived from MAGE genes and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isolated nonapeptides derived from MAGE genes and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated nonapeptides derived from MAGE genes and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1539291