Human phospholipase activating protein and methods for diagnosis

Details Human phospholipase activating protein and methods for diagnosis Human phospholipase activating protein and methods for diagnosis

1990-12-06

1994-03-15

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, 530327, 530328, 530329, 435198, 435 692, C07K 706, C07K 708, C12N 920

Patent

active

052946983

ABSTRACT:
The invention provides methods for detecting elevated levels of phospholipase A.sub.2 activating protein in persons suspected of having rheumatiod arthritis to thereby indicate the presence of rheumatoid arthritis in the person comprising the steps of providing a sample of body fluid or tissue from said person; contacting the sample with an antibody specific for phospholipase A.sub.2 activating protein such that the antibody binds with phospholipase A.sub.2 activating protein in the sample; detecting the antibody thereby indicating the presence of phospholipase A.sub.2 activating protein, whereby elevated levels of phospholipase A.sub.2 activating protein in the sample as compared with levels found in persons not having rheumatoid arthritis indicates the presence of rheumatoid arthritis in the person. Kits and reagents for detecting rheumatoid arthritis are also provided.

REFERENCES:
Clark et al., J. Biol. Chem., vol. 262, No. 9, Mar. 25, 1987, pp. 4402-4406.
Bomalaski et al., Agents and Actions, vol. 27, 3/4, 1989, pp. 425-427.
Bomalaski et al., J. of Immunol., vol. 142, No. 11, Jun. 1, 1989, pp. 3957-3962.
Green, et al., Inflammation, vol. 15, No. 5, issued 1991, pp. 355-367.
Bomalaski, et al., Agents Actions, vol. 27, Nos. 3-4, issued 1989, pp. 425-427.
Bomalaski, et al., J. Immunol., vol. 145, No. 10, issued 1990, pp. 3391-3397.
Clark, et al., Adv. Exp. Med. Biol., vol. 275, issued 1990, pp. 125-144.
Clark, et al., J. Biol. Chem., vol. 252, No. 9, issued 1987, pp. 4402-4406.
EP, A, 0,356,838 (Jain et al.) Mar. 7, 1990.
Heikkila et al., Nature, vol. 328, issued Jul. 30, 1987, pp. 445-449.

Affiliated with

Also associated with

Rating

Human phospholipase activating protein and methods for diagnosis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human phospholipase activating protein and methods for diagnosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human phospholipase activating protein and methods for diagnosis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1536857