Novel sulfonamide fibrinogen receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514183, 514210, 514255, 514318, 514326, 514332, 514333, 514336, 514340, 514341, 514342, 514343, 514374, 514376, 514381, 514383, 514397, 514401, 514422, 540 1, 540544, 544358, 544359, 544360, 544366, 544367, 544372, 546 22, 546193, 546201, 546208, 546209, 546210, 546212, 546213, 546216, 546218, 546221, 546222, 546225, 546232, 546255, 546256, 546268, 546275, 546276, 546278, 546281, 548112, 548237, 548238, 548253, 548254, 5482666, 5483147, 5483151, 5483167, 564 47, 564 84, 564 92, A61K 31445, C07D26722, C07D2

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052927563

ABSTRACT:
A series of non-peptide derivatives of the formula ##STR1## that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.

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patent: 5064814 (1991-11-01), Klein et al.
Ruoslahti et al "New Perspectives in Cell Adhesion" Science 238 491-497 (1987).

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