Method of treating cardiac insufficiency using angiotensin-conve

Details Method of treating cardiac insufficiency using angiotensin-conve Method of treating cardiac insufficiency using angiotensin-conve

1994-12-20

1998-04-28

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3140

Patent

active

057444960

ABSTRACT:
The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 and R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.

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Vincent et al., "Stereoselective Synthesis of a New Perhydroindole Derivative of Chiral Iminodiacid, a Potent Inhibitor of Angiotensin Converting Enzyme," Tetrahedron Letters, 23(16): 1677-1680 (1982).
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Gross, Chemical Abstract 100:1510369 (1983).
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Ader et al, Circulation 61 (5), pp. 931-937 (1980).
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