Process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid

Details Process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid Process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid

1992-08-20

1993-04-20

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546318, C07D21355

Patent

active

052044785

ABSTRACT:
An improved process for the preparation of 2,6-dichloro-5-fluoronicotinoyl chloride is described where a 2,6-dihydroxy-5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro-5-fluoronicotinoyl chloride and subsequent basic hydrolysis affords 2,6-dichloro-5-fluoronicotinic acid.

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