Chemistry: analytical and immunological testing – Involving production or treatment of antibody – Monoclonal antibody
Patent
1991-03-20
1994-03-08
Kepplinger, Esther L.
Chemistry: analytical and immunological testing
Involving production or treatment of antibody
Monoclonal antibody
435 71, 43524027, 435960, 436 63, 436811, 5303882, 5303913, 530836, G01N 3353, G01N 33577, C07K 1528, C12N 512
Patent
active
052926672
ABSTRACT:
A monoclonal antibody which binds preferentially to colonic glycoproteins of cells of persons having ulcerative colitis, compared to colonic glycoproteins of cells of persons not having ulcerative colitis, and diagnostic and therapeutic uses thereof.
REFERENCES:
patent: 4444744 (1984-04-01), Goldenberg
patent: 4650756 (1987-03-01), Old et al.
patent: 4818682 (1989-04-01), Linnane
Podolsky et al., "Glycoprotein Composition of Colonic Mucosa", Gastroenterology 87:991 (1984).
Podolsky et al., "Composition of Human Colonic Mucin", J. Clin. Invest. 72:142 (1983).
Takahashi, "Isolation and Characterization of a Colonic Autoantigen Specifically Recognized by Colon Tissue-Bound Immunoglobulin G From Idiopathic Ulcerative Colitis", J. Clin. Invest. 76:311 (1985).
Vecchi et al., "Development of a Monoclonal Antibody Specifically Reactive to Gastrointestinal Goblet Goblet Cells", Proc. Natl. Acad. Sci. USA 84:3425 (1987).
Culling et al., "A Histochemical Comparison of the O-Acylated Sialic Acids of the Epithelial Mucins in Ulcerative Colitis, Crohn's Disease, and Normal Controls", J. Clin. Path. 32:1272 (1979).
Jacobs et al., "Regional Distribution and Alternations of Lectin Binding to Colorectal Mucin in Mucosal Biopsies from Controls and Subjects with Inflammatory Bowel Disease", J. Clin. Invest. 75:112 (1985).
Smith et al., "Biosynthesis and Secretion of Human Colonic Mucin Glycoproteins", J. Clin. Invest. 80:300, 1987.
Reid et al., "Chemical and Histochemical Studies of Normal/Diseased Human Gastrointestinal Tract, etc.", Histochemical J., 16:253 (1984).
Podolsky et al., "Development of Anti-Human Colonic Mucin Monoclonl Antibodies", 77:1251 (1986).
Podolsky et al., "Human Colonic Goblet Cells", J. Clin. Invest. 77:1263 (1986).
Boland et al., "Abnormal Goblet Cell Glycoconjugates in Rectal Biopsies Associated with an Increased Risk of Neoplasia in Patients, etc.", GUT 25:1364 (1984).
Koprowski et al., "Colorectal Carcinoma Antigens Detected by Hybridoma Antibodies", Somatic Cell Genetics 5:957 (1979).
Boland et al., "Glycoconjugates in the Colons of New World Monkeys with Spontaneous Colitis", Gastroenterology 92:625 (1987).
Podolsky et al., "Colonic Mucin Composition in Primates", Gastroenterology 88:20 (1985).
Podolsky et al., "Emergence of Antigenic Glycoprotein Structures in Ulcerative Colitis Detected Through Monoclonal Antibodies", Gastroenterology 95:371-378, (1988).
Das, et al., "The Production and Characterization of Monoclonal Antibodies to a Human Colonic Antigen Associated with Ulcerative Colitis: Cellular Localization of the Antigen . . . ", J. Immunology 139:77-84 (1987).
Panzini et al, Gastroenterology 94(5 Part 2) A341 (May 1988).
Fournier Deborah A.
Podolsky Daniel K.
Bidwell Carol E.
Kepplinger Esther L.
The General Hospital Corporation
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