Recombinant poxvirus internal cores

Details Recombinant poxvirus internal cores Recombinant poxvirus internal cores

1990-02-14

1993-04-20

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 693, 435 91, 4352351, 435236, 4353201, 424 89, 424 93A, C12P 2100, C12N 701, C12N 704, A61K 3900

Patent

active

052042430

ABSTRACT:
What is described is a modified recombinant poxvirus, such as vaccinia virus, fowlpox virus and canarypox virus, having an internal core containing DNA from a non-pox source in a nonessential region of the poxvirus genome. The recombinant poxvirus is modified by disassociating the internal core from outer membranes of the poxvirus. The DNA codes for and expresses a gene product in a cell cultured in vitro and in a host in vivo without productive replication of the virus in the cell or in the host. What is also described is a vaccine containing the modified recombinant poxvirus for inducing an immunological response in a host inoculated with the vaccine.

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