Method for enhancing the safety of metal-ligand chelates as X-ra

Details Method for enhancing the safety of metal-ligand chelates as X-ra Method for enhancing the safety of metal-ligand chelates as X-ra

1991-11-18

1993-04-20

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

424 9, 514492, 514836, A61K 4904, A61K 3128

Patent

active

052040852

ABSTRACT:
Paramagnetic chelates, as for example, Gadolinium diethylenetriaminepentaacetic acid (DTPA), manganese, ethylenediaminetetraacetic acid (EDTA), and others used as X-ray contrast agents are more toxic acutely when injected in high concentration or at rapid rates. The use of effective amounts of calcium in the form of, calcium chloride, calcium gluconate, or balanced salt solutions substantially reduces this toxicity without the need to add additional ligand.

REFERENCES:
patent: 4176173 (1979-11-01), Winchell et al.
patent: 4478816 (1984-10-01), Ledley et al.
patent: 4647447 (1987-03-01), Gries et al.
patent: 4810782 (1989-03-01), Theodoropulos
patent: 4822594 (1989-04-01), Gibby
patent: 5082649 (1992-01-01), VanDeripe

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