Substituted 9-amino-spiro[cycloalkyl[B]quinoline-2,1'cycloalkane

Details Substituted 9-amino-spiro[cycloalkyl[B]quinoline-2,1'cycloalkane Substituted 9-amino-spiro[cycloalkyl[B]quinoline-2,1'cycloalkane

1988-05-09

1989-02-21

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560 35, 562440, 314278, C07D22120, A61K 31435

Patent

active

048066460

ABSTRACT:
There are disclosed compounds having the formula ##STR1## wherein m is 1 or 2; n is 1 or 2; p is 1-5; x is hydrogen, loweralkyl, cycloalkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, formyl, loweralkylcarbonyl, arylcarbonyl, --SH, loweralkylthio, --NHCOR.sub.2 or --NR.sub.3 R.sub.4 where R.sub.2 is hydrogen or loweralkyl, and R.sub.3 and R.sub.4 are independently hydrogen, loweralkyl or cycloalkyl; R is hydrogen, loweralkyl or loweralkylcarbonyl; and R.sub.1 is hydrogen, loweralkyl, loweralkylcarbonyl, aryl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, oxygen-bridged arylloweralkyl or oxygen-bridged diarylloweralkyl; stereo, optical and geometrical isomers thereof, and pharmaceutically acceptable acid addition salts thereof, which are useful for enhancing memory.

REFERENCES:
patent: 4631286 (1986-12-01), Shutske et al.

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