N-dihydroindolylethyl-sulphonamides

Details N-dihydroindolylethyl-sulphonamides N-dihydroindolylethyl-sulphonamides

1987-04-16

1989-02-21

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548486, 548507, 514418, C07D20934, C07D20916, C07D20914, A61K 3140

Patent

active

048065510

ABSTRACT:
New N-dihydroindolylethyl-sulphonamides are prepared from the corresponding N-indolylethyl-sulphonamides by oxidation or hydrogenation and are useful as active compounds in medicaments. These compounds exhibit a platelet aggregation-inhibiting and thromboxan A.sub.2 -antagonistic action.
The N-dihydroindolylethyl-sulphonamides have the formula ##STR1## in which R.sup.1 represents hydrogen, halogen, trifluoromethyl, carboxyl or alkoxycarbonyl, or represents a group of the formula --S(O).sub.m R.sup.5,
wherein

REFERENCES:
patent: 3833608 (1974-09-01), Rooney
patent: 4636521 (1987-01-01), Coates

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