Method and compositions for reducing neurotoxic injury

Details Method and compositions for reducing neurotoxic injury Method and compositions for reducing neurotoxic injury

1986-11-25

1989-02-21

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514465, 514466, A61K 3136

Patent

active

048065439

ABSTRACT:
A method for reducing adverse effects of neurotoxic injury, which comprises administering to a patient susceptible to neurotoxic injury an effective amount, sufficient to reduce the injury, of a compound which is an enantiomer of an analgesic opioid agonist or antagonist, preferably an opiate agonist having a ring system of the following stereochemistry, which shows only carbon and nitrogen atoms in the rings: ##STR1## The dextrorotatory opiates, dextrorphan and dextromethorphan, are particularly suitable for use in the method of the invention.

REFERENCES:
De Sterons, Medicinal Chemistry, vol. 5, Analgesics (1985) pp. 144-145.
Church et al., Eur. J. Pharmacol. (1985) 111:185-190.
Rothman, J. Neurosci. (1984) 4:1884-1891.
Simon et al., Science (1984) 226:850-852.
Weiloch, Science (1985) 230:681-683.
Choi et al., Soc. Neurosci. Abs. (1986) 12:381.
Isbell et al., J. Pharmacol. Exp. Therap. (1953) 107:524-530.
Jaffe and Martin, "Opioid Analgesics and Antagonists", Goodman and Gillman's Pharmacological Basis of Therapeutics, Alfred Goodman Gillman et al., eds., 7th Edition, 1985, MacMillan and Company, New York, pp. 491-531.

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