Indolothiopyrones

Details Indolothiopyrones Indolothiopyrones

1976-05-10

1977-06-28

Love, Ethel G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D20904

Patent

active

040325377

ABSTRACT:
This invention relates to novel indolothiopyrones having the formula: ##STR1## wherein R.sub.1 is hydrogen, lower alkyl or aryl; R.sub.2 is hydrogen or halogen; and R.sub.7 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, nitro-substituted-aryl, or .omega.-substituted lower alkyl wherein the substituent is: ##STR2## wherein R.sub.4 and R.sub.5 each represent hydrogen, lower alkyl, or together with the nitrogen atom, form a heterocyclic ring; and R.sub.6 is lower alkoxy or amino, and novel intermediates used in their preparation. The indolothiopyrones are prepared by reacting a 3-mercaptoindole with sodium propiolate or a substituted sodium propiolate followed by acidification to obtain an intermediate acid; the intermediate acid cyclizes in the presence of an acid catalyst to obtain the indolothiopyrone structure which may be additionally subjected to halogenation, alkylation or hydrolysis to obtain derivatives having the various substituent groups disclosed. The compounds of this invention are useful in the treatment of angina pectoris and conditions benefitting from the depression of the central nervous system.

REFERENCES:
grant et al., Journ. Amer. Chem. Soc., vol. 82, pp. 2742-2744 (1960).

Affiliated with

Also associated with

Rating

Indolothiopyrones does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Indolothiopyrones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indolothiopyrones will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1520977