Optically active anthracyclinones and process therefor

Details Optically active anthracyclinones and process therefor Optically active anthracyclinones and process therefor

1977-06-02

1979-01-02

Curtis, Allen B.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C 4970

Patent

active

041327217

ABSTRACT:
Optically active anthracyclinones are prepared by reacting an optically active (-) 1,4-dimethoxy-6-hydroxy-6-acetyl-tetralin with a phthalic anhydride in the presence of AlCl.sub.3 or AlBr.sub.3 and an alkali metal chloride at 130-180.degree. C. for 1 to 10 minutes.

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patent: 4077988 (1978-03-01), Arcamone et al.
Chemical Abstracts, vol. 85, No. 19-20, 1/22/75, abstract no. 14 2918j, Faubl, Hermann.
Canadian Jol. of Chem., vol. 49, No. 16 (Sep. 1971), pp. 2712-2718, "Synthetic Studies of Hydronapthacenic Antibiotics, I. The Synthesis of 4-Demethoxy-7-O-methyl Daunomycinone", Wong et al.
Canadian Jol. of Chem., vol. 55 (1973), pp. 466-467, "The Total Synthesis of Daunomycinone" Wong et al.

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