Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-02-23
1998-11-10
Davenport, Avis M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 17, 530329, A61K 3800, A61K 3802, C07K 500, C07K 700
Patent
active
058344330
ABSTRACT:
A method for controlling the growth of tumor tissues, especially small cell lung. Treatment comprises administering to a patient in need thereof, an effective amount of a bombesin/GRP type inhibitor.
Antagonists of bombesin/GRP which are derivatives of naturally occurring bombesin/GRP possessing a thiomethylene or methylene sulfoxide bond connecting the two amino acids on the carboxy terminal end is modified are described. The antagonism is confirmed using conventional competitive binding and biochemical assays as well as conventional physiological tests and the use of these derivatives in a variety of conditions in which bombesin/GRP is implicated is also described.
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Davenport Avis M.
Merrell Pharmaceuticals Inc.
Payne T. Helen
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