Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-05-01
1998-11-10
Walsh, Stephen
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 435325, 4353523, 4351723, 536 2431, 536 231, C12N 1512, C12N 1563
Patent
active
058342427
ABSTRACT:
The present invention provides a new human clathrin-associated protein (CLAPH) and polynucleotides which identify and encode CLAPH. The invention also provides expression vectors, host cells, antibodies and antagonists. The invention also provides methods for the prevention and treatment of diseases associated with expression of CLAPH, as well as diagnostic assays.
REFERENCES:
Kirchhausen, T. et al., "AP17 and AP19, the Mammalian Small Chains of the Clathrin-associated Protein Complexes Show Homology to Yap17p, Their Putative Homolog in Yeast" J. Biol. Chem. 266: 11153-11157 (1991). (GI 191982) (GI 191983).
Nakai, M. et al., "Cloning of the YAP19 gene encoding a putatuve yeast homolog of AP19, the mammalian small chain of the clathrin-assembly proteins" Biochem. Biophys. Acta 1174: 282-284 (1993) (GI 202957) (GI 202928).
Watanabe, T.K. et al., "Cloning, expression pattern and mapping to 12p13.2.fwdarw.p13.1 of CLAPS3, a gene encoding a novel clathrin-adaptor small chain" Cytogen. Cell Genet. 73: 214-217 (1996) (GI 1669532) (GI 1669533).
Dell'Angelica, E.C. et al., "AP-3: an adaptor-like protein complex with ubiquitous expression" EMBO J. 16: 917-928 (1997).
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Seaman, M.N.J. et al., "Cytosolic and Membrane-associated Proteins Involved in the Recruitment of AP-1 Adaptors onto the Trans-Golgi Network" J. Biol. Chem. 271: 25446-25451 (1996).
Dell'Angelica, E.C. et al., (Direct Submission), GenBank Sequence Database (Accession x99459), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1770514) (GI 1770515) (Jan. 1997).
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Bandman Olga
Corley Neil C.
Shah Purvi
Basi Nirmal S.
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Walsh Stephen
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