Polypeptides and antibodies for diagnosing and treating seminoma

Details Polypeptides and antibodies for diagnosing and treating seminoma Polypeptides and antibodies for diagnosing and treating seminoma

1995-12-05

1999-01-12

Stucker, Jeffrey

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

5303873, C12P 2106, C12P 2108

Patent

active

058587233

ABSTRACT:
Polypeptides are disclosed that are useful for diagnosing seminoma. The polypeptides have a sequence that corresponds to the amino acid sequence of the human endogenous retrovirus K10 (HERV-K10). Also disclosed are recombinant human endogenous retrovirus K10 (HERV-K10) env and gag polypeptides that are synthesized using genetic engineering techniques, constructs and processes for producing the recombinant polypeptides, and an assay for detecting the presence of antibodies specific for HERV-K10 env and/or gag polypeptides in human bodily fluids.

REFERENCES:
patent: 5134227 (1992-07-01), Chang et al.
patent: 5175098 (1992-12-01), Watanabe et al.
M. Sauter et al., "Human Endogeneous Retrovirus K10: Expression of Gag Protein and Detection of Antibodies in Patients with Seminomas", J. Virol. 69(1):414-421 (1995).
R. Loewer et al., "Identification of a Rev-Related Protein by Analysis of Spliced Transcripts of the Human Endogenous Retroviruses HTDV/HERV-K", J. Virol. 69(1): 141-149 (1995).
B. Hasenmaier et al., "The Activity of LTRs of the Endogenous Retrovirus HERV-K in Different Cell Lines", J. Cancer Res. Clin.Oncol. 119 suppl 1:54 abstract (1993).
W. Vogetseder et al., "Antibodies in Human Sera Recognizing a Recombinant Outer Membrane Protein Encoded by the Envelop Gene . . .", AIDS Res. Hum. Retroviruses 9(7): 687-694 (1993).
W. Vogetseder et al., "Human Endogenous Retrovirus K Does Not Encode Mouse Mammary Tumor Virus-Related Antigens in Human Breast Carcinomas", AIDS Res. Hum. Retroviruses 11(7):869-872 (1995).
N. Mueller-Lantzsch et al., "Human Endogenous Retroviral Element K10 (HERV-K10) Encodes a Full-Length Gag Homologous 73-kDa Protein and a Functional Protease", AIDS Res. Hum. Retroviruses 9(4): 343-350 (1993).
M. Ono et al., "Mucleotide Sequence of Human Endogenous Retrovirus Genome Related to the Mouse Mammary Tumor Virus Genome", J. Virol. 60(2): 589-598 (1986).
P. Stosiek et al., "Immunohistological Detection of Lymph Node Metastases in the Testicular Center as Quick Section Diagnosis During Retroperitoneal Lymphadenectomy", Path. Res. Pract. 189: 1010-1014 (1993).
K. Boller et al., "Evidence that HERV-K is the Endogenous Retrovirus Sequence that Codes for the Human Teratocarcinoma-Derived Retrovirus HTDV", Virol. 196: 349-353 (1993).
D. Bailey et al., "Production of a monoclonal antibody specific for seminomas and dysgerminomas", Proc. Natl. Acad. Sci. USA 83: 5291-5295 (1986).
N. Bartlett et al., "Serum Markers in Germ Cell Neoplasms", Hemat./Oncol. Clinics N.A. 5(6): 1245-1260 (1991).
A. Marks et al., "A novel anti-seminoma monoclonal antibody (M2A) labelled with technetium-99m: potential application for radioimmunoscintigraphy", Brit. J. Urol. 75: 225-229 (1995).
R. Mariani-Costantini et al., "Ancestry of a Human Endogenous Retrovirus Family", J. Virol. 63(11): 4982-4985 (1989).
A. Shih et al., "Evolutionary Implications of Primate Endogenous Retroviruses", Virol. 182: 495-502 (1991).
E. Larsson et al., "Human Endogenous Proviruses", Current Topics in Microbiol. Immunol. 148: 115-132 (1989).
S. Steinhuber et al., "Disbribution of human endogenous retrovirus HERV-K genomes in humans and different primates", Hum. Genet. 96: 188-192 (1995).
R. Loewer et al., "Identification of human endogenous retroviruses with complex mRNA expression and particle formation", Proc. Natl. Acad. Sci. USA 90: 4480-4484 (1993).

Affiliated with

Also associated with

Rating

Polypeptides and antibodies for diagnosing and treating seminoma does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polypeptides and antibodies for diagnosing and treating seminoma, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polypeptides and antibodies for diagnosing and treating seminoma will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1514333