Pharmaceutical composition for cyclosporines

Details Pharmaceutical composition for cyclosporines Pharmaceutical composition for cyclosporines

1997-01-22

1999-01-12

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424405, 514723, A61K 948

Patent

active

058584013

ABSTRACT:
The invention comprises a stable solution of cyclosporine forming a polar lipid self-emulsifying drug delivery system ("PLSEDDS"). The composition typically consists of cyclosporine dissolved in a polar lipid, such as a medium chain monoglyceride of C.sub.6 -C.sub.12 fatty acids having a monoglyceride content of at least 50% and a surfactant. The composition provided here instantly forms a fine emulsion on exposure to water. The encapsulated dosage form of this composition needs neither a hydrophilic component nor air-tight blister packaging, and is particularly suitable for oral administration.

REFERENCES:
patent: 2870062 (1959-01-01), Stanley et al.
patent: 4388307 (1983-06-01), Cavanak
patent: 4428927 (1984-01-01), Ebert et al.
patent: 4649047 (1987-03-01), Kaswan
patent: 4711902 (1987-12-01), Serno
patent: 4719239 (1988-01-01), Muller et al.
patent: 4722941 (1988-02-01), Echert et al.
patent: 4722999 (1988-02-01), Handschumacher et al.
patent: 4727109 (1988-02-01), Schmidt et al.
patent: 4792449 (1988-12-01), Ausman et al.
patent: 4795643 (1989-01-01), Seth
patent: 4839342 (1989-06-01), Kaswan
patent: 4888239 (1989-12-01), Brox
patent: 4914188 (1990-04-01), Dumont et al.
patent: 4935243 (1990-06-01), Borkan et al.
patent: 4963362 (1990-10-01), Rahman et al.
patent: 4990337 (1991-02-01), Kurihara et al.
patent: 4996193 (1991-02-01), Hewitt et al.
patent: 5047396 (1991-09-01), Orban et al.
patent: 5047512 (1991-09-01), Handschumacher et al.
patent: 5051402 (1991-09-01), Kurihara et al.
patent: 5118493 (1992-06-01), Kelley et al.
patent: 5120710 (1992-06-01), Liedtke
patent: 5154930 (1992-10-01), Popescu et al.
patent: 5206219 (1993-04-01), Desai
patent: 5294604 (1994-03-01), Nussenblatt et al.
patent: 5342625 (1994-08-01), Hauer et al.
patent: 5376381 (1994-12-01), Weiner et al.
patent: 5411952 (1995-05-01), Kaswan
patent: 5431916 (1995-07-01), White
patent: 5444041 (1995-08-01), Owen et al.
patent: 5474979 (1995-12-01), Ding et al.
patent: 5478860 (1995-12-01), Wheeler et al.
patent: 5504068 (1996-04-01), Komiya et al.
patent: 5583105 (1996-12-01), Kovacs et al.
patent: 5589455 (1996-12-01), Woo
patent: 5603951 (1997-02-01), Woo
patent: 5614491 (1997-03-01), Walch et al.
patent: 5635497 (1997-06-01), Molenaar
patent: 5639474 (1997-06-01), Woo
patent: 5639724 (1997-06-01), Cavanak
patent: 5645856 (1997-07-01), Lacy et al.
patent: 5652212 (1997-07-01), Cavanak et al.
patent: 5660858 (1997-08-01), Parikh et al.
patent: 5716928 (1998-02-01), Benet et al.
Copy of Computer Searches.
Certifcate o Analysis on CAPMUL MCM C8, dated Feb. 6, 1997, from Abitec Corp.
Test Results on dl-x-tocopherol USP, dated Jul. 7, 1997, from Hoffman-LaRoche Inc.
Certificate of Analysis for CAPTEX 300, dated Jun. 25, 1996, from Abitec Corp.
Product Information for CAPTEX 300, undated, from Abitec Corp.
Certificate of Analysis for CAPMUL MCM, dated Mar. 17, 1997, from Abitec Corp.
Product Information for CAPMUL MCM, dated Mar. 1994, form Abitec Corp.
Manufacturer's Test Certificate for IMWITOR 308, dated Sept 1, 1995, from Huls AG.
Certificate of Analysis on polysorbate 80, dated Jun. 24, 1996, from Spectrum Quality Products, Inc.
Data Sheet for LABRASOL, dated 1992, form Gattefosse Corp. (2 pages).
Technical Bulletin for CREMOPHOR EL, dated Apr. 1996, from BASF Corp.
Data Sheet for LABRAFAC LIPOPHILE WL 1349, dated 1992 (2 pages).
Product Information on CAPMUL MCM C8, dated Oct. 31, 1996, from Abitec Corp .

Affiliated with

Also associated with

Rating

Pharmaceutical composition for cyclosporines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pharmaceutical composition for cyclosporines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical composition for cyclosporines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1512317