Vaccine containing a Shigella bacterium having an enhanced antig

Details Vaccine containing a Shigella bacterium having an enhanced antig Vaccine containing a Shigella bacterium having an enhanced antig

1997-05-30

1999-01-12

Naff, David M.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Bacteria or actinomycetales

4242521, 4241841, 4242821, 435822, A01N 6300, A61K 4500, C12N 100, C12N 120

Patent

active

058583521

ABSTRACT:
Methods using in vitro processes are disclosed for inducing or enhancing expression of enteric bacterial antigens or virulence factors. The methods, therefore, produce antigenically enhanced bacteria for use in vaccines. Also disclosed are methods for using the antigenically enhanced bacteria as well as the vaccines containing the enteric bacteria. Specifically, a whole enteric bacteria or components thereof, are provided by Shigella species. In addition to this microorganism there are other enteric bacteria, such as Campylobacter species and Helicobacter pylori, which are useful for inducing or enhancing expression of enteric bacterial antigens and/or virulence factors.

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