Process to prepare pyrimidine nucleosides

Details Process to prepare pyrimidine nucleosides Process to prepare pyrimidine nucleosides

1990-08-16

1991-12-31

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544247, C07D49816

Patent

active

050774034

ABSTRACT:
A process for the production of a compound of the formula ##STR1## where R.sub.1 and R.sub.2 each are alkyl C.sub.1 -C.sub.16, aryl, aralkyl, alkenyl, alkynyl, cyano, carboxy and esters, carboximido, N-monosubstituted and N,N-disubstituted carboximido with alkyl, aralkyl, and aryl groups; R.sub.3 is tertiary butyldimethyl silyl, R.sub.4 is tertiarybutyldimethylsilyl, trimethylsilyl, X=O or NH comprising condensing a compound of the formula ##STR2## wherein R.sub.3 and R.sub.4 are as defined above with a compound of either the formula: ##STR3## wherein R.sub.1 and R.sub.2 are as defined above and R.sub.5 is C.sub.1 -C.sub.4 ; in the presence of a reaction-inert solvent at a temperature of from 50.degree.to about 150.degree. C. forming an intermediate and oxidizing the intermediate product, to form the desired compound of formula I. The products are antiviral.

REFERENCES:
Hall, Charles M., et al., "The Synthesis of O.sup.2,2 -Anhydro-5, 6-dihydro Nucleosides", J. Org. Chem. vol. 37, No. 21, 1972, pp. 3290-3293.
Hall et al., J. Org. Chem., vol. 37, No. 21, 1972 pp. 3290-3293.
Ryuzi et al., Chemical Abstract vol. 69, 1968; 524502.

Affiliated with

Also associated with

Rating

Process to prepare pyrimidine nucleosides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process to prepare pyrimidine nucleosides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process to prepare pyrimidine nucleosides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1511383