Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-07-31
1999-09-14
Chan, Christina Y.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 691, 4352523, 4353201, 435325, 435410, C07H 2104
Patent
active
059524839
ABSTRACT:
I.kappa.B-.beta. polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IB-.beta. polypeptides and polynucleotides in the design of protocols for the treatment of inflammatory conditions including but not limited to rheumatoid arthritis, dermatosis (eg. psoriasis), inflammatory bowel disease, autoimmune diseases, tissue and/or organ rejection, Alzheimer's disease, stroke, atherosclerosis, restenosis, cancer, viral infection including but not limited to AIDS, osteoarthritis, osteoperosis, and Ataxia Telangiestasia, among others, and diagnostic assays for such conditions.
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Chu, Z. et al. "Basal phosphorylation of the PEST domain in IkBb regulates its functional interaction with the c-rel proto-oncogene product", Mol. Cell. Bio. 16:5974-5984, 1996.
Chan Christina Y.
Han William T.
King William T.
Nolan Patrick J.
SmithKline Beecham Corporation
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