Method for separating unmodified hemoglobin from cross-linked he

Details Method for separating unmodified hemoglobin from cross-linked he Method for separating unmodified hemoglobin from cross-linked he

Filed on

1995-06-07

Date issued

1999-09-14

Examiner

Tsang, Cecilia J.

Patent Class

Chemistry: natural resins or derivatives; peptides or proteins;

SubClass

Proteins, i.e., more than 100 amino acid residues

SubSubClass

Blood proteins or globulins, e.g., proteoglycans, platelet...

Other Related Categories

530412, 530419, 514 6, C07K 130, C07K 14805

Type

Patent

Status

active

Patent number

059524707

Description

ABSTRACT:
A method for separating unmodified hemoglobin from cross-linked hemoglobin in a hemoglobin solution. The method involves contacting the hemoglobin solution with a least one dissociating agent to form a dissociation solution wherein unmodified tetrameric hemoglobin is dissociated to form hemoglobin dimers. The hemoglobin dimers are then separated from the dissociation solution, while retaining the cross-linked hemoglobin in the dissociation solution.

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