Methods for inhibiting smooth muscle cell proliferation

Details Methods for inhibiting smooth muscle cell proliferation Methods for inhibiting smooth muscle cell proliferation

1998-06-30

1999-09-14

MacMillan, Keith O.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142335, 514320, 514253, 514456, A61K 31535, A61K 31445

Patent

active

059523646

ABSTRACT:
The present invention provides novel methods of lowering serum cholesterol and inhibiting smoother muscle cell proliferation, particularly restenosis, in humans, and inhibiting uterine fibroid disease and endometriosis in women comprising administering to a human/woman in need of treatment an effective amount of a compound of formula I ##STR1## wherein R is C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halo, or trifluoromethyl;

REFERENCES:
patent: 3340276 (1967-09-01), Carney et al.
patent: 3535344 (1970-10-01), Irmscher et al.
patent: 3822287 (1974-07-01), Bolger et al.
patent: 4302453 (1981-11-01), Hauck et al.
patent: 4945086 (1990-07-01), Benitz et al.
patent: 4988735 (1991-01-01), Casagrande et al.
patent: 5280040 (1994-01-01), Labroo et al.
patent: 5283257 (1994-02-01), Gregory et al.
patent: 5284868 (1994-02-01), Dell et al.
patent: 5389646 (1995-02-01), Labroo
patent: 5395842 (1995-03-01), Labrie et al.
patent: 5407947 (1995-04-01), Bryant et al.
patent: 5446061 (1995-08-01), Bryant et al.
Black, L., et al, Journal of Clin. Invest., 93:63-69, (1994).
Srivastave, et al, Ind. J. Physial, Pharmac., 24 No. 1, 43-48, (1980).
Ratna, S. et al., Drug Dev. Res. 7:173-178, (1986).
Bain, S. et al., Maturitas, 27 (Supp.): 144 p. 093, (1997).
Holm, P., et al, Journal of Clin. Invest. 100:4 821-828 (1997).

Affiliated with

Also associated with

Rating

Methods for inhibiting smooth muscle cell proliferation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for inhibiting smooth muscle cell proliferation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for inhibiting smooth muscle cell proliferation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1510198