Propenone derivatives

Details Propenone derivatives Propenone derivatives

1996-11-26

1999-09-14

Powers, Fiona T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514414, 514419, 5462781, 548465, 548494, 548500, A61K 3140, A61K 3144, C07D20912, C07D20932, C07D20940

Patent

active

059523557

ABSTRACT:
The present invention relates to propenone derivatives represented by the following formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, or YR.sup.5 (wherein Y represents S or O; and R.sup.5 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or a substituted or unsubstituted cyclic ether residue); R.sup.2 and R.sup.3 independently represent hydrogen, lower alkyl, or substituted or unsubstituted aralkyl, or alternatively R.sup.2 and R.sup.3 are combined to form substituted or unsubstituted methylene or ethylene; R.sup.4 represents hydrogen, hydroxy, lower alkyl, substituted or unsubstituted aralkyl, lower alkoxy, substituted or unsubstituted aralkyloxy, or halogen; and X represents substituted or unsubstituted indolyl; or pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 4753965 (1988-06-01), Stemerick et al.
patent: 4863968 (1989-09-01), Edwards et al.
patent: 4904697 (1990-02-01), Sunkara et al.
Cancer Research, vol. 54, No. 23 (Dec. 1, 1994), pp. 6106-6114.
Chemical Abstracts, vol. 78, No. 5, Feb. 5, 1973, No. 29910t.
Antonyuk et al., Zh. Obshch. Khim., 42(8), 1706-1714, 1972.

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