Naphthyl compounds and compositions, as estrogen receptor bindin

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514212, 5142388, 514428, 514650, 540609, 544106, 546195, 546205, 548528, 548576, 564337, 564347, 564353, 564354, A61K 31445, C07D21106

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active

059523506

ABSTRACT:
The invention provides a compound of formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical compositions containing a compound of formula I, and methods of using a compound of formula I for inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions including hyperlipidemia, and estrogen dependent cancer.

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Bindal et al. "1,2-diaryl-3,4-dihydronaphthalenes:photofluorogenic lignads for the estrogen receptor" J. Steroid. Biochem. v.23, pp. 929-937, 1985.
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