Human cytosolic isocitrate dehydrogenase

Details Human cytosolic isocitrate dehydrogenase Human cytosolic isocitrate dehydrogenase

1997-12-03

1999-09-14

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 691, 4353201, 536 231, C12Q 168, C12P 2106, C07H 2102

Patent

active

059521775

ABSTRACT:
The invention provides a human cytosolic isocitrate dehydrogenase (HCID) and polynucleotides which identify and encode HCID. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating disorders associated with expression of HCID.

REFERENCES:
Jennings, G.T. et al., "Cytosolic NADP.sup.+ -dependent Isocitrate Dehydrogenase", J. Biol. Chem., 269: 23128-23134, (1994).
Yadav, R.N. Singh and S.N. Singh, "Regulation of NAD-and NADP-Linked Isocitrate Dehydrogenase by Hydrocortisone in the Brain and Liver of Male Rats of Various Ages", Biochim. Biophys. Acta., 633: 323-330, (1980).
Jennings, G.T. and P.M. Stevenson, "A study of the control of NADP.sup.+ -dependent isocitrate dehydrogenase activity during gonadotropin-induced development of the rat ovary", Eur. J. Biochem., 198: 621-625, (1991).
Baumgart, E. et al., "Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome", Proc. Natl. Acad. Sci. USA, 93: 13748-13753, (1996).
Song, B.J., (Direct Submission), GenBank Sequence Database (Accession X69433), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 872120; GI 872121) 1995.
Song, B.J., (Direct Submission), GenBank Sequence Database (Accession 872121), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 872121) 1995.
Kim, Y.O. et al., (Direct Submission), GenBank Sequence Database (Accession U 7681 ), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 706889, GI 706839 Jan. 26, 1996.
Kim, Y.O. et al., (Direct Submission), GenBank Sequence Database (Accession 706839), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 706839) Jan. 25, 1996.
Kim, Y. et al., "Characterization of a cDNA clone for human NAD.sup.+ -specific isocitrate dehydrogenase .alpha.-subunit and structural comparison with its isoenzymes from different species", Biochem. J., 308:63-68, (1995), (GI 706839).
Kullman et al. Genebank Accession No. U62389, Oct. 1996.

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