Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1992-04-10
1996-07-02
Draper, Garnette D.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4353201, 4352401, 435 691, 935 9, 935 66, 530351, 530312, C07H 2104, C07K 1472, C12N 510, C12N 1512, C12N 1563
Patent
active
055323472
ABSTRACT:
The present invention relates to a mammalian melanocyte stimulating hormone receptor. The invention is directed toward the isolation, characterization and pharmacological use of mammalian melanocyte stimulating hormone receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing a mammalian melanocyte stimulating hormone receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize mammalian melanocyte stimulating hormone receptor. The invention also provides methods for screening MSH.sup.R agonists and antagonists in vitro using preparations of receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the MSH.sup.R receptor gene. The invention specifically provides human and mouse MSH.sup.R genes.
REFERENCES:
J. E. Gerst et al. Mol. Pharmacol. 31:81 1987.
F. Libert et al. Science 244:569 1989.
Q.-Y Zhou et al. Nature 347:76-80 Sep. 1990.
Y. Masu et al. Nature 329:836 1987.
Hanneman et al., in Peptide Hormone as Prohormones, G. Martinez, ed. (Ellis Horwood Ltd.: Chichester, UK) pp. 53-82.
DeWied & Jolles, 1982, Physiol. Rev. 62:976-1059.
Shimuze, 1985, Yale J. Biol. Med. 58:561-570.
Tatro & Reichlin, 1987, Endocrinology 121: 1900-1907.
Solca et al., 1989, J. Biol. Chem. 264: 14277-14280.
Siegrist et al., 1991 J. Receptor Res. 11: 323-331.
Cone Roger D.
Mountjoy Kathleen G.
Draper Garnette D.
Spector L.
State of Oregon Acting by and Through the Oregon State Board of
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